Zohydro Guide

ALTTEXTWhat is Zohydro?

Zohyrdo is a strong opioid analgesic (pain killer) drug with a high potential to cause physical and psychological dependence. Zohyrdo is a semi-synthetic opioid made from the alkaloid, Thebaine. It is very similar to Codeine in structure and actions. The active agent, hydrocodone, has been around for more than 70 years in Europe but because of the addiction and abuse potential, the drug never became popular until the late 1980's in the United States.
Once the addictive problems of Heroin and Morphine became well known, it was decided not to make pain killers using morphine substitutes.


Zohydro painkillers have the same active ingredient, hydrocodone, as Vicodin. However, Zohydro is a completely pure form of hydrocodone while Vicodin is a mixture of hydrocodone and the non-addictive painkiller acetaminophen, commonly known as Tylenol.

Being that Zohydro is 100% pure hydrocodone, it is much more susceptible to dependence and addiction.

ALTTEXT For more information on other abused substances please visit our Drug Guide Page

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Typical solid round pills, usually marked with dosage size (30, 40, 80, etc...), varies in color.

Street Names:


Routes of Administration:

  • Chewing
  • Crushing
  • Injecting
  • Sniffing

Short - Term Effects

  • Analgesia-numbness
  • Sedation
  • Euphoria
  • Feelings of Relaxation
  • Respiratory Depression
  • Constipation
  • Papillary Constriction
  • Cough Suppression

Long - Term Effects

  • Can produce severe respiratory depression
  • Skeletal muscle flaccidity
  • Reduction in blood pressure and heart rate
  • Coma
  • Respiratory arrest
  • Death


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